Characterization of the Biocompatibility and Mechanical Properties of Polyurea Organic Aerogels with the Vascular System: Potential as a Blood Implantable Material

Abstract

Our goal was to compare the biocompatibility of Desmodur N3300-derived polyurea aerogels to that of X-MP4-T045 templated mesoporous silica aerogels. The effects of N3300 polyurea aerogels on the vascular system were evaluated by hemolysis, platelet activity, endothelial cell activity, and inflammatory responses. Aerogel morphology was examined using SEM and nano-indentation. Results indicate that N3300 aerogels do not alter blood cell or inflammatory responses and did not absorb proteins. They are compatible with endothelial cells. Overall, N3300 aerogels share similar biocompatibility as X-MP4-T045 aerogels but changes were observed in gel morphology. Therefore, N3300 aerogels may be suitable for various cardiovascular applications.

Keywords:

• Biocompatibility
• blood implantable device
• polyurea aerogels
• relaxation modulus

Acknowledgement

The authors would like to acknowledge the nano-indentation work conducted by Mr. Cheng Chen, and also would like to thank the NSF (Award Number DMR 0907291) for financial support, and the Bayer Corporation USA for their generous supply of isocyanates.