The Effect of Polysaccharide Plugs on In Vitro Release Kinetics of Drug From Pulsatile Device and Evaluation of Its In Vivo Targeting Efficiency

Abstract

The objective was to investigate the effect of different polysaccharide plugs on pulsatile device of Aceclofenac. The Aceclofenac microspheres were prepared in four batches, with Eudragit L-100 and S-100 (1:2) by varying drug to polymer ratio and evaluated for the particle size, drug content, and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of Pulsatile device. In vitro release mechanism of pulsatile device studied with different kinetics model. The X-ray study on humans pointed out the capability of the system to release drug in colon region.

Keywords:

• Drug release kinetics
• in vivo X-ray study
• polysaccharides
• pulsatile

Acknowledgment

The authors would like to thank Dr. Bhavesh B. Patel (MD, DMRE) Ex. Radiologist at B.J. Medical College and Civil Hospital, (Ahmedabad, India) for helpful comments and advice during X-ray study. The authors are grateful to MJRP College of Health Care and Allied Science, (Jaipur, India) for providing the necessary facilities to carry out this study. Also they wish to thank Redson Pharmaceutical PVT. LTD. and Sunrise remedies LTD., Ahmedabad, for providing Aceclofenac and polymers as a gift samples.

Notes

^a Microspheres equivalent to 100 mg of Aceclofenac.

All values are expressed as mean ±SD.

^a n = 3. **Average of three determinants.