Synthesis, Characterization, and Release Dynamic of Acetylsalicylic Acid From Acetylsalicylic Acid/Poly(vinylalcohol-co-ethylene) Membrane

Abstract

A series of poly(vinylalcohol-co-ethylene)/acetylsalicylic acid blends (PEVA/AcSa) of different AcSa contents were prepared and characterized by the solubility test, differential scanning calorimetry, and scanning electron microscopic analyses. The results revealed that AcSa was perfectly soluble in PEVA at certain composition and uniformly distributed throughout the polymer matrix. The release dynamic of AcSa from PEVA/AcSa material was studied at body temperature during 92 h in which the influence of AcSa initially incorporated in PEVA, the pH of media, the membrane thickness, and the stability of AcSa release rate on the release dynamic were detailed.

Keywords:

• Acetylsalicylic acid
• drug release
• membrane
• mixture
• poly(vinylalcohol-co-ethylene)

Acknowledgment

The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding the work through the research group project No. RGP-VPP-025.

Notes

^a During 10 h of the release process.

^b During 30 h of the release process.