Development of Urea Crosslinked Thin Film for Biomedical Application

Abstract

Bioadhesive thin film was prepared from gelatin using urea as plasticizer as well as crosslinker. Viscosity of the solution showed a decreasing trend with increasing heating time. Nevertheless, viscosity and pH increased with increasing urea content and heating time to a certain level. Mechanical properties and fluid drainage capability of the films of blend solutions were also evaluated. Tensile strength showed a mixed behavior with urea content and heating but flexibility increased with urea content. Besides, crosslinked film showed no cytotoxic effect rather fluid absorption capability was improved. All of these results suggest its potentiality for effective wound dressing material.

Keywords:

• Crosslinking
• cytotoxicity
• gelatin
• urea bridge