Alginate and Sulfanilamide Based DDS with Antibacterial Activity

Abstract

The aim was to obtain alginate based, biological active delivery systems, with prolonged release of sulfanilamide. The influences of alginate gel concentration as well as the influence of sulfanilamide content were studied. The presence of sulfanilamide assures antimicrobial activity while alginate and magnetite are responsible with the slow release kinetic. The presence of magnetite is also important because allows magnetic field guidance of the alginate/Fe₃O₄/sulfanilamide beads. The obtained DDS were characterized by FTIR, SEM, release profile in saline solution (0.9% NaCl), and antimicrobial activity against Escherichia coli.

Keywords:

• Alginate
• drug delivery system
• magnetite
• sulfanilamide

Acknowledgment

This study is supported by the PN-II-PT-PCCA-2011–3.2–0284: “Novel nanostructured prosthetic tubular devices with antibacterial and antibiofilm properties induced by physicochemical and morphological changes,” funded by the National University Research Council in Romania.