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Abstract
The present study was designed to formulate buccal bioadhesive patches of pentazocine hydrochloride employing aminated and sulfated derivatives of tamarind seed polysaccharide (TSP). The patches were evaluated for their physicomechanical characteristics, swelling index, in vitro release, and in vivo release profiles. The in vitro release of the drug was found to depend on the swelling index of the polymers. The sulfated TSP patches were releasing drug at a faster rate as compared to aminated TSP patches. The oral administration of aminated patches to rats was found to enhance the bioavailability of pentazocine hydrochloride 2.8 times as compared to oral solution.
Notes
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