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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 63, 2014 - Issue 10
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Original Articles

Biocompatibility of Modified Bionanocellulose and Porous Poly(ϵ-caprolactone) Biomaterials

Bartlomiej Grobelski Faculty of Pharmacy, Medical University of Łódź, Łódź, Poland
,
Radoslaw A. Wach Institute of Technical Biochemistry, Łódź University of Technology, Łódź, PolandCorrespondence[email protected]
,
Agnieszka Adamus Institute of Applied Radiation Chemistry, Łódź University of Technology, Łódź, Poland
,
Alicja K. Olejnik Institute of Applied Radiation Chemistry, Łódź University of Technology, Łódź, Poland
,
Karolina Kowalska-Ludwicka Institute of Technical Biochemistry, Łódź University of Technology, Łódź, Poland
,
Marek Kolodziejczyk Institute of Technical Biochemistry, Łódź University of Technology, Łódź, Poland
,
Stanislaw Bielecki Institute of Technical Biochemistry, Łódź University of Technology, Łódź, Poland
,
Janusz M. Rosiak Institute of Applied Radiation Chemistry, Łódź University of Technology, Łódź, Poland
&
Zbigniew Pasieka Department of Experimental Surgery, Medical University of Łódź, Łódź, Poland
 show all
Pages 518-526 | Received 22 May 2013, Accepted 29 Sep 2013, Published online: 13 Mar 2014
 
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Abstract

Biocompatibility of modified bionanocellulose (BC) and porous poly(ϵ caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential.

Acknowledgment

The authors thank Dr. M. Ludwicki of Department of Automation and Biomechanics of the Technical University of Łódź for providing software for SEM picture analyzing.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/gpom.

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