Synthesis and Characterization of Chitosan Based Multilayer and pH Sensitive Co-Polymeric System for the Targeted Delivery of 5-Fluorouracil, an In Vitro Study

Abstract

The principle aspiration is to develop a core shell carrier system for 5-Fluorouracil. Trisodiumcitrate crosslinked chitosan containing 5-Fluorouracil coated with cellulose acetate acts as core and copolymer of N-vinyl-2-pyrrolidone, 2-hydroxyethylmethacrylate, and itaconic acid act as shell. SEM, FTIR, and XRD studies were undertaken to characterize the samples. Swelling experiments were performed as a function of time, temperature, pH, and in simulated gastric and intestinal pH. Swelling factor was calculated for three different ions. Drug loading efficiency and in vitro release studies was done and compared. Drug delivery mechanism was found out by using Peppa's equation.

Keywords:

• Chitosan
• drug delivery
• free radical graft copolymerization
• in vitro release
• swelling controlled

Acknowledgments

The authors thank Department of Chemistry, University of Kerala, India, for providing laboratory facilities.

Notes

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