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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 63, 2014 - Issue 13
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Original Articles

Mesoporous Silica Nanoparticles (MCM-41) Coated PEGylated Chitosan as a pH-Responsive Nanocarrier for Triggered Release of Erythromycin

Ali Pourjavadi Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, IranCorrespondence[email protected]
&
Zahra Mazaheri Tehrani Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran
Pages 692-697 | Received 03 Aug 2013, Accepted 22 Oct 2013, Published online: 09 May 2014
 
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Abstract

A pH-responsive drug delivery system based on core shell structure of mesoporous silica nanoparticle (MSN) and chitosan-PEG copolymer was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), scanning electron microscope (SEM), and high-resolution transmission microscope (HR-TEM) techniques. In order to improve compatibility MSN and drug, mesoporous nanosilica was modified by 3-aminopropyl triethoxysilane. The release of erythromycin (a macrolide antibiotic) as a model drug was investigated in two pHs, 7.4 and 5.5.

Notes

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