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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 63, 2014 - Issue 15
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Original Articles

Bioengineering of Dental Pulp Stem Cells in a Microporous PNIPAAm-PLGA Scaffold

R. Salehi Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; School of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
,
M. Aghazadeh School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
,
M. R. Rashidi Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
,
N. Samadi School of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
,
Sh. Salehi School of Medicine, Department of Anesthesiology, Uromieh University of Medical Sciences, Uromieh, Iran
,
S. Davaran School of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran
&
M. Samiei School of Dentistry, Tabriz University of Medical Sciences, Tabriz, IranCorrespondence[email protected]
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Pages 767-776 | Received 11 Sep 2013, Accepted 26 Dec 2013, Published online: 27 May 2014
 
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Abstract

In the present article a novel bio absorbable polymeric scaffold using poly(N-isopropyl acrylamide-block-poly(L-lactide-co-glycolide) (PNIPAAm-b-PLGA) copolymers is developed for in vitro culture of human dental pulp stem cells (DPSCs). The processing of porous scaffolds has been carried out by emulsion freeze-drying and salt leaching out methods. DPSCs were cultured on scaffolds for up to 14 days. The morphology of the scaffolds, cell viability and interaction between DPSCs and scaffold was characterized by using SEM. The results of cells implantation indicated that scaffold has good cell biocompatibility. Therefore PNIPAAm-PLGA scaffolds have great potential to be used as cell carrier in tissue engineering.

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