Preparation of Magnetic pH-Sensitive Film With Alginate Base for Colon Specific Drug Delivery

Abstract

The aim of this work was to prepare alginate base film and its properties and application in drug delivery field. In order to achieve this, naproxen as a drug and magnetic nanoparticles were placed into the films. Sodium alginate could be crosslinked and form a gel under extremely mild and environmentally friendly conditions without using toxic solvents and reactants. The polymeric films were analyzed by DSC, SEM, and FT-IR spectroscopy. The in vitro release profiles were established separately in both enzyme-free simulated gastric (pH 1) and intestinal fluids (pH 7.4).

GRAPHICAL ABSTRACT

Keywords:

• Colon specific drug delivery
• nanomagnetic films
• natural polymers
• pH-sensitive hydrogels
• sodium alginate

Notes

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