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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 64, 2015 - Issue 5
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Original Articles

Radioiodinated Magnetic Nanoparticles Conjugated With Moxifloxacin: Synthesis and In Vitro Biological Affinities

Ozge Kozgus Guldu Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey
,
Perihan Unak Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, TurkeyCorrespondence[email protected]
,
E. Ilker Medine Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey
,
F. Baris Barlas Department of Biochemistry, Faculty of Sciences, Ege University, Bornova, Izmir, Turkey
,
F. Zumrut Biber Muftuler Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Bornova, Izmir, Turkey
&
Suna Timur Department of Biochemistry, Faculty of Sciences, Ege University, Bornova, Izmir, Turkey; Institute of Drug Abuse Toxicology & Pharmaceutical Sciences, Ege University, Bornova, Izmir, Turkey
Pages 253-259 | Received 18 Mar 2014, Accepted 26 May 2014, Published online: 03 Nov 2014
 
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Abstract

Magnetic nanoparticles (MNPs) were synthesized and coated with tetraethyl orthosilicate and aminosilane to create functional amino groups. Moxifloxacin (MXF) was conjugated to the modified MNPs using glutaraldehyde as crosslinker. Finally, MXF conjugated magnetic nanoparticles were radiolabeled and their biological affinities such as cell incorporation ratio, cytotoxicity, and their potential as cell imaging probe were investigated using A-549 cells.

GRAPHICAL ABSTRACT

Notes

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