Influence of Anionic Surface Charged Biocompatible Dendrimer With a Photosensitizer, Protoporphyrin IX, on Human Red Blood Cells: A Spectroscopic Investigation

Abstract

A biocompatible anionic dendrimer with carboxylic acid and phenolic hydroxyl functional groups at the surface of every half and full generations was designed by condensing phloroglucinol and succinic acid and its hemolytic effect on red blood cells was studied. The study reveals that the anionic surface charged dendrimer exhibits hemocompatibility and satisfies the reduction of dark toxicity of photosensitizer when loaded inside the nanocarrier, one of the prime requirements for a drug delivery system in photodynamic therapy applications.

GRAPHICAL ABSTRACT

Keywords:

• Anionic biocompatible dendrimer
• drug delivery system
• hemolysis
• photosensitizer
• protoporphyrin IX

Acknowledgement

The author is very thankful to Dr. S. Ramesh, associate professor and Head, Centralised Instrumentation Lab, Madras Veterinary College, Vepery, Chennai-7, for providing TEM facility.