Synthesis and Characterization of Synthetic and Natural Nano Hydroxyapatite Composites Containing Poloxamer Coated Demineralized Bone Matrix as Bone Graft Material: A Comparative Study

Abstract

The present study aimed to developing a bone graft material containing poloxamer (P), demineralized bone matrix (DBM), and nano hydroxyapatite derived from bovine bones (NHA) or prepared via synthetic route (SHA). Thermogravimetric analysis indicates P + DBM + SHA composite to be more stable compared to the P + DBM + NHA composite. XRD results revealed better crystallinity in P + DBM + SHA compared to P + DBM + NHA. The SEM show uniform and homogenous distribution of poloxamer and DBM on the porous nano hydroxyapatite matrix. This shows that the composite P + DBM + SHA can serve as osteoinductive materials.

GRAPHICAL ABSTRACT

Keywords:

• Bone graft
• composite
• demineralized bone matrix
• hydroxyapatite
• poloxamer