PEG-co-Polyvinyl Pyridine Coated Magnetic Mesoporous Silica Nanoparticles for pH-Responsive Controlled Release of Doxorubicin

Abstract

In the present work a pH responsive drug nanocarrier based on magnetic mesoporous silica nanoparticles (MMSN) and polyethylene glycol-co-polyvinyl pyridine (PEG-co-PVP) was prepared. The core-shell nanocarrier was formed due to electrostatic interaction between protonated polyvinyl pyridine and surface modified MMSN with carboxylate groups. This carrier was used for pH-controllable doxorubicin release. The maximum release was occurred at pH 5.5 (pH of endosomes). This carrier was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, UV-Vis spectrophotometer, scanning electron microscope, and high-resolution transmission electron microscope techniques. Also the zeta potential value and dynamic light scattering were measured. All characterizations confirmed the core-shell structure of the drug nanocarrier.

GRAPHICAL ABSTRACT

Keywords:

• Doxorubicin
• magnetic mesoporous silica nanoparticles
• nanocarrier
• PEGylated polyvinyl pyridine
• pH-responsive