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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 64, 2015 - Issue 15
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Original Articles

Electrospun Biopolyesters as Drug Screening Platforms for Corneal Keratocytes

Pedram AzariDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
,
Ng Sook LuanDepartment of Physiology, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
,
Seng Neon GanDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
,
Rosiyah YahyaDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
,
Chiow San WongPlasma Technology Research Center, Physics Department, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
,
Kien Hui ChuaDepartment of Physiology, Faculty of Medicine, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia
&
Belinda Pingguan-MurphyDepartment of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, MalaysiaCorrespondence[email protected]
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Pages 785-791 | Received 03 Oct 2014, Accepted 14 Mar 2015, Published online: 21 May 2015
 
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Abstract

In vitro drug screening techniques provide rapid and easy to analyze data, while saving a lot of animals from being sacrificed. An important part of any in vitro drug screening platform is a biomaterial which promotes cell growth and proliferation. The potential of electrospun scaffolds made of polyhydroxybutyrate (PHB), poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV), and polycaprolactone (PCL) were studied to serve as drug screening platform for corneal keratocyte tissues. The results showed that the proliferation rate was slightly higher for PCL and PHBV on day 7. Gene expression results showed that PCL was the best in maintaining keratocyte genes.

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