Control of Breast Cancer Using Organotin Polymers

Abstract

The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure/property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC₅₀ values are primarily dependent on the nature of the Lewis base but the CI₅₀ is dependent on both the nature of the Lewis base and Lewis acid. A number of products exhibit CI₅₀ values greater than two including a number of organotin polyethers such as those derived from diethylstilbestrol, dienestrol, short-chained dibutyltin polyethers, and hydroquinone derivatives. In most of these cases the MDA-MB-231 cells exhibit greater inhibition compared to the estrogen receptor (ER) MCF-7 cells. The organotin polymers generally exhibit a superior ability to inhibit MCF-7 and MDA-MB-231 breast cell growth compared to the standard cisplatin.

GRAPHICAL ABSTRACT

Keywords:

• Anticancer drugs
• breast cancer
• interfacial polycondensation
• MCF-7 cell line
• MDA-MB-231 cell line
• organotin polymers
• tin-containing polymer