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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 65, 2016 - Issue 8
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Original Articles

Hemocompatible interface control via thermal-activated bio-inspired surface PEGylation

Mei-Chan SinR&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan, Taiwan
,
Wen-Lin LinR&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan, Taiwan
,
Jeff Chang-Hung ChenR&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan, Taiwan
,
Akon HiguchiDepartment of Chemical and Materials Engineering, National Central University, Jhong-Li, Taoyuan, Taiwan
,
Jie ZhengChemical & Biomolecular Engineering, The University of Akron, Akron, OH, USA
,
Arunachalam ChinnathambiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
,
Sulaiman Ali AlharbiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
&
Yung ChangR&D Center for Membrane Technology and Department of Chemical Engineering, Chung Yuan Christian University, Chung-Li, Taoyuan, Taiwan;Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi ArabiaCorrespondence[email protected]
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Pages 409-420 | Received 25 Jun 2015, Accepted 07 Dec 2015, Published online: 08 Feb 2016
 
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ABSTRACT

A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently codeposited onto versatile substrates of both organic and inorganic materials. Thermal-activated codeposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine, as the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.

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