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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 65, 2016 - Issue 13
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Original Articles

Functional poly(p-phenylene)s as targeting and drug carrier materials

Bahar GulerFaculty of Science, Department of Biochemistry, Ege University, Izmir, TurkeyView further author information
,
Huseyin AkbulutDepartment of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul, TurkeyView further author information
,
Caner GeyikInstitute on Drug Abuse, Toxicology & Pharmaceutical Sciences, Ege University, Izmir, TurkeyView further author information
,
F. Baris BarlasFaculty of Science, Department of Biochemistry, Ege University, Izmir, TurkeyView further author information
,
Dilek Odaci DemirkolFaculty of Science, Department of Biochemistry, Ege University, Izmir, TurkeyView further author information
,
Hakan CoskunolInstitute on Drug Abuse, Toxicology & Pharmaceutical Sciences, Ege University, Izmir, TurkeyView further author information
,
Suna TimurFaculty of Science, Department of Biochemistry, Ege University, Izmir, Turkey;Institute on Drug Abuse, Toxicology & Pharmaceutical Sciences, Ege University, Izmir, TurkeyCorrespondence[email protected] [email protected]
View further author information
&
Yusuf YagciDepartment of Chemistry, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Turkey;Center of Excellence for Advanced Materials Research CEAMR) and Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi ArabiaView further author information
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Pages 653-659 | Received 08 Nov 2015, Accepted 21 Feb 2016, Published online: 02 May 2016
 
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ABSTRACT

Polymers have a substantial attention in drug delivery systems owing to the diverse intrinsic advantages. It is important to carry the drug to the target site and release to exert its effects. Herein, poly(p-phenylene)s with amino and poly(ethylene glycol) substituents (PPP-NH2-g-PEG) were used as a carrier for doxorubicin (DOX), an anticancer drug, and haloperidol, a sigma receptor targeting ligand. Both human cervix adenocarcinoma cell line (HeLa) and human keratinocyte cell line (HaCaT) having different Sigma receptor 1 (SigmaR1) expression levels were compared. HeLa was found to express twofold SigmaR1 compared to HaCaT cells. Cell imaging studies showed that, DOX cell uptake was higher in HeLa cells when targeted with haloperidol.

GRAPHICAL ABSTRACT

Additional information

Funding

Ege University, Aliye USTER Foundation, and Istanbul Technical University, Research Fund, are acknowledged for financial support.

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