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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 66, 2017 - Issue 8
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Original Articles

Thermosensitive elastin-derived polypeptide hydrogels crosslinked by genipin

Jin ZhaoTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaView further author information
,
Yufang YanTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaView further author information
,
Yuezai ShangTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaView further author information
,
Yang DuTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaView further author information
,
Lixia LongTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaView further author information
,
Xubo YuanTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaView further author information
&
Xin HouTianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, P. R. ChinaCorrespondence[email protected]
View further author information
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Pages 369-377 | Received 06 Dec 2015, Accepted 24 Jul 2016, Published online: 12 Apr 2017
 
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ABSTRACT

In this paper, first, elastin-derived peptides (EPs) with low molecular weight were prepared by acid degradation. Second, elastin-derived peptide hydrogels were fabricated by crosslinking EP with genipin. EP exhibited an inverse transition temperature, and the inverse transition temperature (Tt) could be adjusted by changing the concentration and molecular weight of EP, pH, and adding salt. The freeze-dried EP hydrogels were obviously three-dimensional network structure and the property of EP hydrogel can be optimized by dosage of genipin. Differential scanning calorimetry (DSC) tests and the swelling ratio changing with temperature showed the crosslinked EP hydrogels were still thermosensitive and exhibited a negative swelling behavior. The compression modulus of EP hydrogels can even reach 39.4 kPa, surpassing many other elastin-based hydrogels. This genipin crosslinked EP hydrogel is a good biological material and has great potentiality in tissue engineering.

GRAPHICAL ABSTRACT

Additional information

Funding

This work was financially supported by National Natural Science Foundation of China (Grants No. 51103095).

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