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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 66, 2017 - Issue 9
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Original Articles

3D scaffolds coated with nanofibers displaying bactericidal activity for bone tissue applications

Kevin D. De SáCICS-UBI—Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
,
Daniela R. FigueiraCICS-UBI—Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
,
Sónia P. MiguelCICS-UBI—Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
,
Tiago R. CorreiaCICS-UBI—Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal
,
Abílio P. SilvaCentro de Ciência e Tecnologia Aeroespaciais, Universidade da Beira Interior, Covilhã, Portugal
&
Ilídio J. CorreiaCICS-UBI—Health Sciences Research Centre, University of Beira Interior, Covilhã, PortugalCorrespondence[email protected]
Pages 432-442 | Received 24 Apr 2016, Accepted 10 Sep 2016, Published online: 12 Apr 2017
 
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ABSTRACT

Bone-limited capacity to fully repair large defects requires the development of new implants. In this context, new approaches have been used to promote bone regeneration and also to avoid the side effects associated with the therapeutics currently used in the clinic. Herein, 3D tricalcium phosphate/alginic acid scaffolds were produced and then coated with an electrospun mesh loaded with two different antibacterial agents, silver nanoparticles, and salicylic acid. The obtained results showed that the produced scaffolds have suitable mechanical properties, swelling, biodegradation, biomineralization activity, enhanced cellular adhesion/proliferation and bactericidal activity, and features essential for bone regeneration.

GRAPHICAL ABSTRACT

Acknowledgment

Sónia P. Miguel acknowledges a PhD fellowship from FCT (SFRH/BD/109563/2015).

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