Preparation and characterization of carvedilol-loaded poly(d,l) lactide nanoparticles/microparticles as a sustained-release system

ABSTRACT

Carvedilol poly(d,l)-lactide nanoparticles/microparticles were prepared. The size and morphology of the developed particles were optimized to study the carvedilol release profile by studying the effect of organic solvents and polymer amount through atomic force microscopy analysis. Spherical particles were obtained with a minimum size of 125 nm in the case of acetone and a maximum size of 970 nm in the case of dichloromethane affording microparticles formation. The interaction was confirmed by differential scanning calorimeter and Fourier transform infrared. The in vitro release profile of the multicompartment system (pure carvedilol, loaded nanoparticles and microparticles) has shown a sustained release with Korsmeyer–Peppas with T lag model.

GRAPHICAL ABSTRACT

KEYWORDS:

• Atomic force microscopy
• hydrophobic drug
• poly(d,l)-lactide nanoparticle/microparticles
• sustained-release system

Acknowledgments

Authors acknowledge Cynthia Mizyed from the Language Center-An Najah National University for editing the article. Authors thank Dr Saed Khammash for the scientific discussion. Authors also acknowledge Dr Ramzi Shawahna for kinetic modeling analysis and thank the department of chemistry at An Najah National University for the FTIR analysis. Majd Bani-Odeh thanks An Najah National University for the teaching and research assistant scholarship.