Synthesis and characterization of polyethylene glycols conjugated to polybutylcyanoacrylate nanoparticles

ABSTRACT

This study aimed to evaluate the cytotoxicity effects of various polyethylene glycols (PEGs), and construction and characterization of polybutylcyanoacrylate (PBCA) nanoparticles. Cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on rat glioma C6 cell line, and PBCA nanoparticles were prepared by emulsion polymerization method. Also, the nanoparticles were characterized by dynamic light scattering and scanning electron microscopy. The findings showed that PEGs were approximately safe and cytotoxicity was inversely proportional with their molecular weights. In addition, the size of nanoparticles were increased with reducing molecular weights of PEGs. PEGs with negligible cytotoxicity and stabilizing functionality were demonstrated in this study.

GRAPHICAL ABSTRACT

KEYWORDS:

• MTT
• nanoparticle
• polybutylcyanoacrylate
• polyethylene glycol

Acknowledgments

The authors are thankful to their colleagues of Pilot Nanobiotechnology Department of Pasteur Institute of Iran for their invaluable help in performing the study.