Stabilized polymeric nanoparticle from amphiphilic mPEG-b-polyaspartamides containing ‘click’ functional groups

ABSTRACT

The synthesis of a series of poly(ethylene glycol) and polyaspartamide-based block copolymers containing azide and alkyne function groups and its micelle formation in aqueous solution were described. The self-assembly behavior of these amphiphilic copolymers in aqueous media to form nanosized micelle and the core-crosslinking reaction to convert them to stable nanoparticle were investigated. The particle size distributions were measured by dynamic light scattering. The resulting nanogel, prepared by click reaction within the mixed micelle core, has been shown to exhibit stability upon dilution and also in the presence of SDS, a small-molecule surfactant, suggesting the potential use as carrier for current drug delivery system.

GRAPHICAL ABSTRACT

KEYWORDS:

• Amphiphilic copolymer
• click reaction
• core-crosslinking
• polymeric micelle

Additional information

Funding

This work was supported by Samsung Research Fund, Sungkyunkwan University, 2014.