Development of bacterial cellulose incorporating silk sericin, polyhexamethylene biguanide, and glycerin with enhanced physical properties and antibacterial activities for wound dressing application

ABSTRACT

Bacterial cellulose (BC) has been applied for wound dressing application. In this study, physical and biological properties of the BC dressing were improved by incorporation of silk sericin (SS), polyhexamethylene biguanide (PHMB), and glycerin. The glycerin incorporation reduced dehydration rate and wound adhesion of the BC dressing in a concentration-dependent manner. PHMB, an antiseptic agent, provided antibacterial activity against Gram-positive and Gram-negative bacteria. Meanwhile, SS would enhance collagen and tissue formation in wounds. Finally, we confirmed that the BC dressing incorporating SS, PHMB, and glycerin was safe to be used as a medical material according to ISO 10993-6 standard.

GRAPHICAL ABSTRACT

KEYWORDS:

• Bacterial cellulose
• glycerin
• polyhexamethylene biguanide
• silk sericin
• wound dressing