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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 67, 2018 - Issue 9
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Original Articles

Preparation of hemin polymer monolithic column and its application in the separation of proteins and small molecules

Xueying LiCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaView further author information
,
Jing ZhaoExperimental Center of Hebei University, Baoding, ChinaView further author information
,
Beijiao CuiCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaView further author information
,
Yiming LiCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaView further author information
,
Doudou ZhangCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaView further author information
,
Haiyan LiuCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaCorrespondence[email protected]
View further author information
,
Ligai BaiCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaView further author information
,
Hongyuan YanCollege of Pharmaceutical Sciences, Hebei University, Baoding, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Baoding, ChinaView further author information
&
Yong WangCollege of Basic Medical Science of Hebei University, Baoding, ChinaView further author information
 show all
Pages 589-595 | Received 12 May 2017, Accepted 08 Jul 2017, Published online: 12 Sep 2017
 
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ABSTRACT

A poly(hemin-co-C16-co-TEGDA) monolith was prepared using hemin and 1-hexadecene (C16) as monomers; triethylene glycol dimethacrylate (TEGDA) as crosslinking agent; N,N-dimethylformamide and isopropyl alcohol as porogens; and dibenzoyl peroxide and N,N-dimethyl aniline as initiators in 50 × 4.6 mm i.d. stainless steel column. The morphology and structure of the monolith were characterized by scanning electron microscopy and nitrogen adsorption/desorption isotherm measurement, respectively. Compared with poly(C16-co-TEGDA) monolith, poly(hemin-co-C16-co-TEGDA) monolith had better mechanical properties, higher permeability, and better separation ability. The prepared monolith was used to separate not only proteins but also small molecules.

GRAPHICAL ABSTRACT

Additional information

Funding

The study was funded by National Natural Science Foundation of China (No. 21175031, 21575033, 21505030), the Natural Science Foundation of Hebei Province (No. B2015201024, B2015201085), and the Natural Science Foundation of Hebei University (No. 2014-05).

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