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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 67, 2018 - Issue 13
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Original Articles

Thermal-responsive hydrogels for sublingual administration of Ondansetron™

José Filipe AlmeidaDepartment of Chemical Engineering, Chemical Process Engineering and Forest Products Research Centre (CIEPQPF), University of Coimbra, Coimbra, Portugal;Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, PortugalView further author information
,
Paula FerreiraDepartment of Chemical Engineering, Chemical Process Engineering and Forest Products Research Centre (CIEPQPF), University of Coimbra, Coimbra, PortugalCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3393-4427View further author information
ORCID Icon,
Patricia AlvesDepartment of Chemical Engineering, Chemical Process Engineering and Forest Products Research Centre (CIEPQPF), University of Coimbra, Coimbra, PortugalORCID Iconhttp://orcid.org/0000-0002-8943-8329View further author information
ORCID Icon,
António LopesInstituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, PortugalView further author information
&
Maria H. GilDepartment of Chemical Engineering, Chemical Process Engineering and Forest Products Research Centre (CIEPQPF), University of Coimbra, Coimbra, PortugalORCID Iconhttp://orcid.org/0000-0003-0657-7751View further author information
ORCID Icon
Pages 765-775 | Received 08 May 2017, Accepted 02 Sep 2017, Published online: 13 Oct 2017
 
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ABSTRACT

Thermo-sensitive hydrogels were prepared by grafting N-isopropylacrylamide (NIPAAm) onto chitosan and dextran. The grafting reactions were performed during variable periods of time and different films were obtained. To prepare a drug-delivery system for sublingual delivery of Ondansetron™, this drug was entrapped in the films. Elemental analysis results showed that the amount of poly(NIPAAm) in the final films increased with reaction time, influencing their lower critical solution temperature and swelling behavior. Also, drug release profile depended on grafting extension as well as on the temperature, as the release of Ondansetron™ presented a more sustained-like profile at physiologic temperature.

GRAPHICAL ABSTRACT

Acknowledgments

José Filipe Almeida (SFRH/BD/19707/2004), Paula Ferreira (SFRH/BPD/86338/2012), and Patrícia Alves (SFRH/BPD/69410/2010) gratefully acknowledge FCT for the financial support.

Additional information

Funding

This work was supported by the Fundação para a Ciência e a Tecnologia [Grant Number SFRH/BPD/69410/2010,SFRH/BPD/86338/2012].

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