ABSTRACT
This work studied the eluting behavior of ciprofloxacin, meropenem, and ceftazidime (and their mixtures) with that of gentamicin from antibiotic-loaded bone cements (ALBCs). In vitro release was followed by UV–Vis for 30 days and a semiempirical eluting model that considers the processes of dissolution and diffusion were proposed: . The antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus of the prepared ALBCs was also evaluated. The results showed that the amount of antibiotic released increased when ciprofloxacin/meropenem or ciprofloxacin/ceftazidime was used and that their antibacterial inhibitory effect against microorganisms tested was improved as a consequence of the synergistic effect.
GRAPHICAL ABSTRACT
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Contributions of authors
LMA: Research promoter, UV–Vis and microbiological tests, data analysis and writing of the paper. APMR: Microbiological tests, data analysis, and writing of the paper. JAMF, DLRH, ORG, OELL: Microbiological tests and data analysis. JADGM, GFE: UV-Vis tests, data analysis, and writing of the paper.