Preparation of thermosensitive microcapsules and application on the controllable drug delivery of ibuprofen

ABSTRACT

To reduce the side effects of ibuprofen caused by prolonged or overdosed treatment on the human body, a series of thermosensitive poly(N,N′-methylene bisacrylamide-co-N-isopropylacrylamide) microcapsules were synthesized to control the release of ibuprofen by their thermosensitive properties. The release curves exhibited excellent controllable behavior, which turned from burst release to perfect sustained release by changing the ambient temperature from 25°C (<LCST, lower critical solution temperatures) to 37°C (>LCST). In addition, the NIPAm content and the shell thickness can be conveniently controlled during the polymerization processes, which will affect the drug release rate according to the temperature stimuli.

GRAPHICAL ABSTRACT

KEYWORDS:

• Distillation precipitation polymerization
• drug release
• ibuprofen
• microcapsules
• thermosenstive

Additional information

Funding

The authors acknowledge the financial support for this work from the National Natural Science Foundation of China (grant numbers 21504063 and 51678409); The Science and Technology Plans of Tianjin (grant number 16PTSYJC00110); Tianjin Higher Education Science and Technology Fund Planning Project (grant number 20110506); and Natural Science Foundation of Tianjin City (grant number 17JCQNJC08700).