Biocompatibility and degradability of alginate-poly-L-arginine microcapsules prepared by high-voltage electrostatic process

ABSTRACT

To explore biocompatibility and degradability of alginate-poly-l-arginine (APLA) microcapsules prepared by high-voltage electrostatic process, this study investigated cytotoxicity, blood compatibility, acute toxicity, and in vivo biocompatibility and degradability of APLA microcapsules. The results showed that the uniform APLA microcapsules almost had no cytotoxicity within 1.0 mg/mL, and their degradation products promoted cell proliferation. APLA microcapsules had excellent hemocompatibility even at 200 mg/mL, and their extract products did not create acute toxicity even at 5,000 mg/kg. The inflammatory responses induced by APLA microcapsules were moderate and decreased with time, and APLA microcapsules could be degraded and phagocytized by tissue cells.

GRAPHICAL ABSTRACT

KEYWORDS:

• Alginate
• biocompatibility
• degradability
• electrospraying
• microcapsule
• poly-L-arginine

Additional information

Funding

This paper was supported by the National Natural Science Foundation of China (No. 81502115), the Natural Science Foundation of Fujian Province of China (No. 2017J01529), the Joint Funds for the Innovation of Science and Technology, Fujian Province (No. 2016Y9041), the Outstanding Young Scientific Research Personnel Training Plan in Colleges and Universities of Fujian Province (No. 2016B022), the Fujian Provincial Health and Family Planning Commission Fund (No. 2015-1-74), and the Research Foundation of Educational Commission of Fujian Province (No. JA15221).