Ellagic acid containing collagen-chitosan scaffolds as potential antioxidative bio-materials for tissue engineering applications

ABSTRACT

In this study, chitosan and collagen based scaffolds loaded with ellagic acid were synthesized with an aim to incorporate antioxidant properties within the supporting matrix. Structural characterization of the scaffolds by X-ray diffraction and Fourier transform infrared spectroscopy confirmed the presence of ellagic acid within the chitosan-collagen matrix. The ‘fabricated’ scaffolds exhibited sustained release of ellagic acid in phosphate buffered saline for 120 h. The scaffolds were biocompatible and supported the recovery of COS 7 cells from the oxidative stress arising due to UV irradiation. Such antioxidant incorporated scaffolds present a potential approach in managing chronic wounds by eliminating ROS.

GRAPHICAL ABSTRACT

KEYWORDS:

• Antioxidants
• biocompatible polymers
• chitosan
• collagen
• ellagic acid
• ROS

Acknowledgements

The authors would like to acknowledge Central facility, BITS Pilani K K Birla Goa Campus for the help in characterization of the scaffolds.

Additional information

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.