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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 68, 2019 - Issue 10
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Avermectin/polyacrylate nanoparticles: preparation, characterization, anti-UV and sustained release properties

Guan-Quan LinSchool of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, P.R. China; ;Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Guangzhou, P.R. ChinaView further author information
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Hua-Yao ChenSchool of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, P.R. China; ;Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Guangzhou, P.R. ChinaView further author information
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Hong-Jun ZhouSchool of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, P.R. China; ;Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Guangzhou, P.R. ChinaCorrespondence[email protected]
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Xin-Hua ZhouSchool of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, P.R. China; ;Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Guangzhou, P.R. ChinaCorrespondence[email protected]
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&
Hua XuSchool of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, P.R. China; ;Guangzhou Key Lab for Efficient Use of Agricultural Chemicals, Guangzhou, P.R. ChinaView further author information
Pages 582-589 | Received 26 Oct 2017, Accepted 28 Apr 2018, Published online: 07 Jan 2019
 
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Abstract

In an effort to reduce the dose of drugs and in order to improve drug efficacy, avermectin (AVM) was encapsulated by amphipathic polyacrylic ester (PAE) via self-assembly. The experimental results indicated that the AVM/PAE nanoparticles were spherical in shape, homogeneous dispersion, and had a core-shell structure, the particle size ranged from 172.7 nm to 337.8 nm, the highest encapsulation efficiency and loading capacity were 62.11 and 25.65%. The anti-UV property has been significantly improved. Consistent with the Korsmeyer–Peppas model, the release rate was observed to be higher upon decreasing Tg and increasing the core-shell ratio.

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Funding

This research was supported by National Natural Science Foundation of China [Grant No. 21576303, 21606262], Science and Technology Program of Guangzhou, China [Grant No. 201604020054, 201707010473], Ordinary University Innovation Project of Guangdong Province [Grant No. 2016KTSCX062].

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