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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 68, 2019 - Issue 10
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Articles

Electrospun polycaprolactone/gelatin/bioactive glass nanoscaffold for bone tissue engineering

Keyvan ShiraniFaculty of New Sciences and Technologies, Semnan University, Semnan, Iran;
,
Mohammad Sadegh NourbakhshDepartment of Materials and Metallurgical Engineering, Central Administration of Semnan University, Semnan University, Semnan, Iran; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-5252-4047
ORCID Icon &
Mohammad RafieniaBiosensor Research Center, Department of Advanced Medical Technology, Isfahan University of Medical Sciences, Isfahan, Iran
Pages 607-615 | Received 27 Feb 2018, Accepted 26 May 2018, Published online: 09 Jul 2018
 
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Abstract

Polycaprolactone scaffolds, polycaprolactone/gelatin, and polycaprolactone/gelatin/bioactive glass scaffolds were prepared with ratios of 50/50, 25/75, and 75/25 for polymers and 5 wt% for the bioactive glass via electrospinning and then were characterized using. The results indicated that by adding gelatin and bioactive glass to polycaprolactone scaffold, the diameter of fiber decreased from 557 to 167 nm. The results showed growth of apatite layer on the scaffolds after immersion in simulated body fluid for 28 days. The results of mechanical test revealed that by adding bioactive glass to scaffolds, the ultimate tensile strength and Young's modulus increase about two folds.

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