Preparation of Chitosan-based nanocomposites and biomedical investigations in bone tissue engineering

Abstract

Chitosan (CS)/Bioglass (BG)/Hydroxyapatite (HA)/Halloysite nanotube (HNT) nanocomposites were deposited on titanium (Ti) by electrophoretic deposition (EPD). The nanostructures with the uniform distribution of ceramic particles into CS polymer were yielded. In vitro experiment depicted CS/BG/HA/HNT is precipitated with apatite particles by immersion into corrected simulated body fluid (C-SBF) at 37 °C. Furthermore, In vitro bioactivity, biomineralization, and cell attachment indicated that all of the coatings have a desirable apatite induced ability and cell compatibility. Finally, biodegradability of CS-BG-HA/HNT nanocomposite verified the degradation ratio of CS-BG-HA-HNT is 4 times more than that of CS-BG-HA.

Graphical Abstract

Keywords:

• Bioactivity
• biocompatibility
• biodegradation
• cell attachment
• chitosan
• nanocomposite