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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 68, 2019 - Issue 14
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Articles

Suppressing the growth of HL-60 acute myeloid leukemia cells by chitosan coated anthraquinone nanoparticles in vitro

Fatimah Redah AlassaifDepartment of Central Military Laboratory & Blood bank, Prince Sultan Military Medical City, Riyadh, Saudi Arabia;
,
Eman Redah AlassaifDepartment of Clinical Biochemistry, Almana General Hospital, Dammam, Saudi Arabia;
,
Santosh Rani ChavaliGenetics Laboratory, Pediatrics Department, Texas Tech University Health Sciences Center, Lubbock, TX, USA;
&
Jeevitha DhanapalBiologicals Department, Labmate (Asia) Private Limited, Chennai, IndiaCorrespondence[email protected]
Pages 819-826 | Received 26 Apr 2018, Accepted 05 Aug 2018, Published online: 01 Oct 2018
 
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Abstract

The aim of this work was to formulate Anthraquinone (AQ) loaded Chitosan (CS) nanoparticles using ionic gelation technique. The shape and size of the nanoparticles was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta sizer and zeta potential. The drug release was studied and confirmed the sustained release of the drug. The cytotoxic effects were tested in-vitro against acute myeloid leukemia (HL-60) cells. Apoptosis investigations including cellular uptake, DNA fragmentation, and flow cytometry evaluation of the chitosan-anthraquinone nanoparticles was conducted. These results conclude that CS-AQ NPs have the ability to act against HL-60 cells.

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