Abstract
Embolization microspheres were prepared through two steps. The microspheres demonstrated regular sphericity with a main size distribution in the range of 100 µm ∼ 270 µm. An anticancer drug doxorubicin could be loaded into the microspheres with high loading rates from 21% to 32% due to physical and ionic interaction of carboxyl groups in the microspheres and amino groups in doxorubicin. The drug could be controlled released at different pH conditions. The blank microspheres were biodegradable, non-cytotoxic, and the drug-eluting embolization microspheres could be potentially applied as embolic agents in interventional therapy.
Graphical Abstract
Preparation scheme of the embolization CSOA microspheres.
Disclosure statement
The authors declare that they have no conflict of interest.