Advanced search
Publication Cover
International Journal of Polymeric Materials and Polymeric Biomaterials Volume 68, 2019 - Issue 17
Submit an article Journal homepage
387
Views
11
CrossRef citations to date
0
Altmetric
Articles

Preparation of physically crosslinked PVA/HLC/SA hydrogel and exploration of its effects on full-thickness skin defects

Hong PanShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China; ;Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China; ;Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, ChinaView further author information
,
Daidi FanShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China; ;Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China; ;Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, ChinaCorrespondence[email protected]
View further author information
,
Chenhui ZhuShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China; ;Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China; ;Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, ChinaView further author information
,
Zhiguang DuanShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China; ;Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China; ;Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, ChinaView further author information
,
Rongzhan FuShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China; ;Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China; ;Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, ChinaView further author information
&
Xian LiShaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China; ;Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China; ;Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, ChinaView further author information
Pages 1048-1057 | Received 14 Jul 2018, Accepted 15 Sep 2018, Published online: 07 Jan 2019
 
Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days

Abstract

In this study, single factor experiments and orthogonal test were designed to fabricate a novel poly(vinyl alcohol) (PVA), human-like collagen (HLC) and sodium alginate (SA) composite hydrogel as wound dressings. The obtained hydrogel dressing was soft, elastic and breathable with uniform macro pores, and it remains soft after lyophilization which restore to the original appearance after absorbing a large amount of water. In vivo full-thickness skin defects treated with the hydrogel dressings in rabbit revealed that the hydrogel promoted wound healing through accelerating reepithelization and the growth of collagen fibers. All the results demonstrated the great potential of the hydrogel as wound dressing.

Graphical Abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was financially supported by the National Natural Science Foundation of China [21476182, 21606179]; Shaanxi Key Laboratory of Degradable Biomedical Materials Program [2015SZSj42, 2014SZS07P05].

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,070.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.