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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 3
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Articles

Sorafenib loaded pluronic F127-lithocholic acid micelles for prostate cancer therapy: Formulation, optimization, and in vitro evaluation against LNCaP cells

Noha NasehiDepartment of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran; View further author information
,
Jaleh VarshosazDepartment of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran; ORCID Iconhttp://orcid.org/0000-0001-9333-5798View further author information
ORCID Icon,
Somayeh TaymouriDepartment of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6089-8367View further author information
ORCID Icon,
Mahboobeh RostamiDepartment of Medicinal Chemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran; ORCID Iconhttp://orcid.org/0000-0002-5895-7230View further author information
ORCID Icon,
Vajihe AkbariDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran; View further author information
&
Loghman FiroozpourDrug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, IranView further author information
Pages 158-172 | Received 05 May 2018, Accepted 23 Nov 2018, Published online: 07 Jan 2019
 
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Abstract

In present study, sorafenib loaded nanomicelles were prepared with synthesized pluronic F127 - lithocholic acid by film hydration method. The optimized micelles were spherical showing particle size of 319.36 nm, zeta potential of -11.96 mV, encapsulation efficiency of 87.31%, loading efficiency of 14.87% and release efficiency of 30.1%. Sorafenib loaded nanomicelles showed negligible hemolysis activity on RBC, indicating excellent hemocompatibility of pluronic F127 - lithocholic acid. The drug free nanomicelles showed no cytotoxicity against L929 cells by using MTT assay. However, micellar sorafenib showed more anti-proliferation effect on LNCaP and DU145 cells as compared with free sorafenib.

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Disclosure statement

The authors report no conflicts of interest.

Additional information

Funding

The authors wish to thank the Research Vice Chancellery of Isfahan University of Medical Sciences for supporting this work.

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