Development of biocompatible and biofilm-resistant silver-poly(methylmethacrylate) nanocomposites for stomatognathic rehabilitation

Abstract

Recurrent prosthesis fracture and microbial contamination of the tissue bed or prosthetic materials remain the major clinical challenge for successful intraoral/faciomaxillary rehabilitation. Biocompatible and biofilm-resistant silver nanoparticle (AgNPs) based on poly(methyl methacrylate) was successfully developed by a compression-molding technique. The AgNP-loaded PMMA were characterized using TEM, SEM, FT-IR and XRD analysis. The nanocomposites were found to be biocompatible and biofilm-resistant against Streptococcus mutans and Candida albicans. Mechanical performance of the nanocomposite was statistically analysed and modulus of elasticity was theoretically predicted using four models. The biomaterial developed in this study can be effectively used for stomatognathic rehabilitation.

Graphical Abstract

Keywords:

• AgNPs
• anti bio-film property
• antimicrobial analysis
• constrained region
• mechanical performance
• PMMA

Acknowledgments

The authors N.K. and S.T. would like to thank DST Nano Mission, PURSE and FIST Programmes, and UGC – Government of India through the SAP program for financial support. The author M.M. acknowledges ARRS Grant “L2-8179”. One of the authors, S.G. thanks Dr. Nina Recek for SEM/EDX analysis and Dr. Ita Junkar for plasma treatment at Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia and Dr. Indu Raj, Dr. Mohammed Arif P, Dr. Jiji Abraham, Dr. Joshi K.S. and Mr Anu A.S. for the valuable discussions and assistance in experiments during the course of the work.