AgNPs loaded microemulsion using gallic acid inhibits MCF-7 breast cancer cell line and solid ehrlich carcinoma

Abstract

The objective of this present work is to optimize and prepare silver nanoparticles(AgNPs) in Dioctyl sodium sulfosuccinate (AOT) microemulsion (ME) for oral use and to investigate its antibacterial and anticancer activity in vitro and in vivo. In vitro drug release study confirmed that faster release of drug at the tumor cells compared to the blood circulation. It also showed a potential antibacterial activity against pathogenic bacteria. The optimized AgNPs loaded ME confirmed significant cytotoxicity against MCF-7 cancer cell line with IC50 16.72 ± 0.014 μg/mL and significant reduction in solid Ehrlich tumor growth in compared to the control, placebo and pure drug.

Graphical Abstract

Keywords:

• Antimicrobial activity
• MCF-7 cell line
• microemulsion
• silver nanoparticles
• solid Ehrlich carcinoma

Acknowledgments

The authors are grateful to the Amity Institute of Nanotechnology, Cancer Research Laboratory, Amity Institute of Pharmacy, Noida, India for providing an excellent research environment to complete this work. Also, thanks to National Research Facility (NRF) IIT Delhi, India for providing Characterization facility.

Disclosure statement

No potential conflict of interest was reported by the authors.