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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 69, 2020 - Issue 9
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Articles

Novel Tragacanth Gum-Entrapped lecithin nanogels for anticancer drug delivery

Chetna VermaDepartment of Chemistry, Shoolini University, Solan, India; ;Bioengineering Laboratory Department of Textile Technology, Indian Institute of Technology, New Delhi, India;
,
Poonam NegiDepartment of Pharmacy, Shoolini University, Solan, India; Correspondence[email protected]
,
Deepak PathaniaDepartment of Environmental Science, Central University of Jammu, Jammu, India
,
Sadiya AnjumBioengineering Laboratory Department of Textile Technology, Indian Institute of Technology, New Delhi, India;
&
Bhuvanesh GuptaBioengineering Laboratory Department of Textile Technology, Indian Institute of Technology, New Delhi, India; Correspondence[email protected]
Pages 604-609 | Received 20 Nov 2018, Accepted 14 Mar 2019, Published online: 12 Apr 2019
 
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Abstract

Nanogels are functional particles that may be used to deliver bioactive molecules in targeted drug delivery systems. In the present work, we have investigated the preparation of cisplatin (CP) loaded Tragacanth Gum (TG)-lecithin (LC) nanogels by nanoemulsion process. These nanogels exhibit polygonal core-shell structure in which CP particles are embedded in the TG core of the nanogels and remain covered by LC as shell. Varying concentration of CP were added in the nanogel and the shape and size of the nanogels was investigated. Nanogels were characterized by dynamic light scattering analysis as well. Sustained release of CP from the CP-loaded nTG-LC nanogels as drug was observed in controlled manner under physiological saline.

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