Cyanoacrylate-encapsulated calcium peroxide achieved oxygen-sustained release and promoted wound healing

Abstract

Sustained oxygen release is important to many oxygen-requiring situations. Developing composite materials capable of releasing oxygen in diverse circumstances have potential use in aquaculture, environmental remediation, and wound healing, et al. In this study, a composite material poly-11-CaO₂ was developed by encapsulation of calcium peroxide in a biodegradable crosslinking cyanoacrylate (poly-LKJ11). CaO₂ physically dispersed inside the polymer depot. Poly-11-CaO₂ achieved sustained oxygen release in water environment, that the DO concentration of water could be increased for more than 25 days in a N₂ bubbled bottle model. Poly-11-CaO₂ could also release oxygen on skin surface, thereafter, a poly-11-CaO₂ contained plaster improved dermal wound healing in a rat model.

GRAPHICAL ABSTRACT

KEYWORDS:

• Calcium peroxide
• cyanoacrylate
• oxygen release

Conflicts of interest

There are no conflicts to declare.

Additional information

Funding

The work presented here was supported by grant Z171100001117095 of the Beijing Nova Program, and by grant 81573345 of the National Natural Science Foundation of China.