Poly(d,l-lactide-co-glycolide) nanospheres within composite poly(vinyl alcohol)/aloe vera electrospun nanofiber as a novel wound dressing for controlled release of drug

Abstract

In this paper, poly(d,l-lactide-co-glycolide) (PLGA) nanospheres loading with a protein drug were incorporated in poly(vinyl alcohol)/Aloe vera (PVA/AV) nanofibers by electrospinning as a novel wound dressing. The influence of AV and PLGA nanospheres on the physical characteristics, antibacterial activity, and drug release behavior of the composite nanofibers were studied. A successful composite nanofiber production was observed by scanning electron microscopy. The release behavior showed a prolonged release with the addition of PLGA nanospheres. Antimicrobial activities against Staphylococcus aureus and Escherichia coli were found with AV content. The results indicated that the PVA/AV/PLGA nanofibers warrant further attention for wound-healing applications.

Graphical Abstract

Keywords:

• Aloe vera
• antibacterial
• composite
• drug release
• electrospinning
• nanofiber
• PLGA nanosphere
• polyvinyl alcohol
• wound dressing

Acknowledgements

We are grateful for funding from Center of Excellence on Petrochemical and Materials Technology and Grant for Terminal Executive Staff, Chulalongkorn University.