https://orcid.org/0000-0001-5719-2187
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Abstract
Novel amphiphilic poly(DMAEMA)-block-poly(NVP-co-BA-co-AEM) (BP83-1) forms stable micelles and BP83-1/pDNA complexes possessing controlled size, charge and enhanced aggregation degree. It was found that the formation of the micelles by BP83-1 is necessary for successful DNA binding and compaction. The polyamphiphile micelle aggregation degree defined their crucial effect on the compaction and morphology of polyplexes. Strong compaction of the DNA upon interaction with polymer at CMC value, positive charge, and high stability of the polyplex are key factors promoting the penetration of DNA through bio-surfaces that define the efficiency of gene delivery in mammalian cells.
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Disclosure statement
The authors declare no conflicts of interest.
Additional information
Funding
The authors express their thanks to TUBITAK, Turkey for the financial support to project numbered 109S258 (SBAG-UKRAYNA-3) and the State Committee of Ukraine for Science and Innovation for funding of the project numbered M/417-2011.