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International Journal of Polymeric Materials and Polymeric Biomaterials Volume 71, 2022 - Issue 1
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Articles

Drug-loaded polymeric nanoparticles: a review

Karine Cappuccio de CastroScience and Technology Institute, Federal University of Alfenas (UNIFAL-MG), Rodovia José Aurélio Vilela, Poços de Caldas, Minas Gerais, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9782-4767View further author information
ORCID Icon,
Josiel Martins CostaScience and Technology Institute, Federal University of Alfenas (UNIFAL-MG), Rodovia José Aurélio Vilela, Poços de Caldas, Minas Gerais, BrazilORCID Iconhttps://orcid.org/0000-0002-7097-1342View further author information
ORCID Icon &
Maria Gabriela Nogueira CamposScience and Technology Institute, Federal University of Alfenas (UNIFAL-MG), Rodovia José Aurélio Vilela, Poços de Caldas, Minas Gerais, BrazilORCID Iconhttps://orcid.org/0000-0002-1962-9453View further author information
ORCID Icon
Pages 1-13 | Received 08 Apr 2020, Accepted 16 Jul 2020, Published online: 07 Aug 2020
 
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Abstract

Polymeric nanoparticles are one of the most studied strategies in modern medicine for drug encapsulation. The researchers' main interest is a formulation capable of administering the medication in a controlled mode and specific site. In this context, stimulus-responsive nanoparticles are highlighted, as these systems can have long circulation times, achieve the disease site, and improve intracellular medication administration. Therefore, this review addressed trends in drug delivery mechanisms and the influence of internal and external stimulus sources on the stimulus-responsive nanocarriers. Moreover, conventional and emerging methods for the synthesis of polymeric nanoparticles were reviewed.

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Disclosure statement

No conflict of interest was reported by the author(s).

Additional information

Funding

This research was supported by CAPES – Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance code 001).

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