Degradable poly(catechin) nanoparticles as a versatile therapeutic agent

Abstract

Poly(catechin) (p(CAT)) nanoparticles (NPs), 173 ± 4 nm was prepared as a therapeutic agent with hydrolytic degradability affording sustainable CAT release over 20 d at carcinogenic conditions, pH 5.5 and 37.5 °C. Cell viability studies on MC38 colon cancer cells revealed the anticancer potential of p(CAT) NPs with 691 µg/mL IC₅₀ value while being well-tolerated by nonmalignant CCD841 CoN colon cells at 72 h incubation-time. P(CAT) NPs showed effective antioxidant capacity with 241 ± 7 and 456 ± 54 µg/mL of GA equivalency of total phenol content (TPC), and total flavonoid content (TFC) values and 1.19 ± 0.8 µmol/g Trolox equivalent antioxidant capacity by 2,2'-Azino-bis-(3-ethylbenzothioazoline-6-sulfonic acid (ABTS^•+) scavenging assay.

Graphical Abstract

Keywords:

• Catechin
• CAT nanoparticles
• antioxidant
• cancer therapy
• metal chelating
• antidiabetic

Additional information

Funding

We are grateful for the support from The Scientific and Technological Research Council of Turkey [BIDEB-2219 Postdoctoral Research program-grant number 1059B191801146]. This work also funded partially by the University of South Florida start-up fund to NS.