A core-shell insulin/CS-PLGA nanoparticle for enhancement of oral insulin bioavailability: in vitro and in vivo study

Abstract

This study aims to prepare a nanodrug system for insulin delivery and controlled release with Poly(lactic acid-glycolic acid) (PLGA) as the shell and polyethylene glycol-chondroitin sulfate as the core to enhance its oral administration bioavailability. The insulin/CS-PLGA nanoparticles (NPs) with an average size of about 150 nm and regular spherical shape were obtained and showed good biocompatibility and relative high drug loading. Insulin can be controlled release according to the environmental pH and retained its original structure. The oral administration of insulin/CS-PLGA NPs showed a relatively higher hypoglycemic effect than that of insulin, indicating the NPs is a potential oral delivery system to enhance insulin bioavailability.

Graphical Abstract

Keywords:

• CS-PLGA nanoparticles
• drug delivery
• insulin
• oral administration
• orthogonal experiment

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China (52173208), the Major project of Wuxi Health Commission (Z201702), the Medical Research Project of Jiangsu Provincial Commission of Health and Family Planning (H2018023), the Health Scientific Research Project of Wuxi Municipal Health and Health Commission (Q201942, M202031), the Priority Academic Program Development of Jiangsu Higher Education Institutions, and the Qing Lan Project of Yangzhou University.