Abstract
This study aims to develop quetiapine (QTP)-loaded β-cyclodextrin (β-CD) based co-polymeric thiolated polyethylene glycol-poly(lactic-co-glycolic acid) (t-PEG-PLGA) nanoparticles (QTP@β-CD-t-PEG-PLGA) by transesterification process. As a result, the ex-vivo bioadhesion study shows good bioadhesion because of the thiolation of PEG (t-PEG), which can interrelate through mucin and expand the retention time. In-vitro release study demonstrates the QTP release to 20 h (∼98.76%). Herein, sulfhydryl ligands can form disulfide bonds with cysteine-rich mucus areas that increased the viscosity of mucin and accordingly drug retention. Hence, it can be significant accomplishment for nose to brain drug targeting in psychotic disorder management.
Graphical Abstract
Acknowledgments
The authors acknowledge Kavayitri Bahinabai Chaudhari North Maharashtra University Jalgaon for financial assistance (NMU/11A/VCRMS/Budget-2016-17/pharmacy-9/84/2017) to complete the research project effectively. The authors are thankful to Management and Principal, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur for providing the necessary facilities to carry out the project smoothly.
Disclosure statement
No potential conflict of interest was reported by the author(s).