Strontium-doped mesoporous bioactive glass microspheres developed for drug delivering and enhancing the bioactivity of polylactic acid scaffolds

Abstract

Strontium-doped mesoporous bioactive glass microspheres (Sr-MBGMs) were prepared by sol–gel method for delivering loxoprofen sodium (LX) drug. The loading capacity of the prepared Sr-MBGMs for LX drug was affected by the initial concentration of the drug solution and adsorption time. The LX-loaded Sr-MBGMs obtained under optimum conditions were coated with polydopamine (LX/Sr-MBGMs@PDA) and incorporated into the aminated modified poly-l-lactic acid nanofibrous matrix to develop a functional composite scaffold for bone tissue engineering applications. The in vitro studies revealed that the incorporation of the LX/Sr-MBGMs@PDA could promote cell proliferation and biomineralization, indicating that the as-developed composite scaffolds possessed an improved cell viability and osteogenic ability.

Graphical Abstract

Keywords:

• Aminated modification
• bioactivity
• loxoprofen sodium
• mesoporous bioactive glass microsphere
• polylactic acid nanofibrous scaffolds
• strontium-doped

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by Natural Science Foundation of Fujian Province [2020J02033, 2022Y0005, 2019J01546 and 2021J01060], Fuzhou Science and Technology Project [2021-P-037], Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma [2020Y2014], Medical innovation project of Fujian Provincial Health Commission in 2020 [2020CXB037] and Fuzhou health innovation platform construction project [2020-S-wp3, 2021-S-wp2].