Abstract
Polyelectrolyte multilayer (PEM) was developed through layer-by-layer (LbL) adsorption on sodium alginate on negatively charged lipid polymer hybrid nanoparticles (LPHNPs) for the delivery of Buspirone hydrochloride (BUH). The resultant BUH-LPHNPs (F2) showed a mean particle size of 166 ± 4.2 nm and zeta potential of −30.5 ± 1.52 mV. The BUH-LPHNPs were found to be stable and demonstrated controlled drug release kinetics. Further, the pharmacokinetic studies revealed a 3.29-fold rise in the oral bioavailability of formulation (F2) than BUH (pure). Thus, PEM fabricated through LbL technology could be explored for overcoming the bioavailability issue and targeted delivery for potential drug candidates.
Graphical Abstract
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Acknowledgments
The authors are thankful to Unichem Laboratory Ltd. (Goa, India) for providing the gift sample of buspirone hydrochloride, Gattefosse India Pvt. Ltd (Mumbai, India) for providing the GMS, Lipoids, Phospholipd GmbH, Nattermannallee, Germany for providing the soya lecithin, and Indoco Remedies (Mumbai, India) for providing the sodium alginate as a gift sample. The authors are also thankful to STIC (Kochi, India) for providing the TEM facility.
Disclosure statement
No potential conflict of interest was reported by the author(s).